I had a horrible nightmare this morning...
...someone adjusted the settings on one of my guitar pedals!
I watched the Masterclass with Tom Morello (https://www.masterclass.com/classes/tom-morello-teaches-electric-guitar), and he mentions that he set the knobs in his amp 30 years ago to something he liked, and never changed it. I was never a RATM fan, but I really loved the class and it was an amazing way of fighting GAS (gear acquisition syndrome).
I still have GAS, but when I buy a new pedal, I spend an hour or two adjusting the settings, then leave it at optimal.
Wow... I'm the opposite. When I first started buying pedals one of my biggest influences (he still is!) was Adrian Belew, who would play a flanger as if it was a musical instrument in its own right. He had an EH "Electric Mistress" unit stuck half-way up his mic stand, which you can see in this video: https://www.youtube.com/watch?v=SvJe25wA-e8
I've been an inveterate knob-twiddler ever since.
For some effects, tweaking is kinda important; if you use delay or reverb, adjusting the predelay and delay so that the reflections happen on a beat (or a subdivision of the beat) in the song will stop them making the mix muddy and really make the song shine. Tracks like Pink Floyd's "Run Like Hell", U2's "Pride (In The Name Of Love)" and "Where The Streets Have No Name" and Van Halen's "cathedral" wouldn't be the same without that echo hitting on the dotted 8th note...
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